Studies on human platelet protease activity
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چکیده
منابع مشابه
Studies on human platelet protease activity.
SOLUBILIZED PROTEIN DERIVED FROM HUMAN PLATELETS WAS FRACTIONATED BY DEAE CELLULOSE COLUMN CHROMATOGRAPHY AND ANALYZED FOR PROTEASE ACTIVITY USING THREE SUBSTRATES: denatured bovine hemoglobin, alpha casein, and purified plasminogen-free human fibrinogen. A protein fraction was found with proteolytic activity which was heat labile and not attributable to plasmin. The activity was not potentiate...
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D URING the last ten years evidence has been presented from different laboratories that fibrinogen may not be essential for thrombin-mediated platelet aggregation.14 Although the presence, in platelets, of a thrombinsensitive protein other than fibrinogen has been reported from this laboratory and also by other workers,5 #{176} there is no report of its isolation, structure, physicochemical pro...
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Gangliosides, glycosphingolipids which contain sialic acid, were studied in human platelets. They represented 0.5% of the platelet lipids and accounted for 6% of the total neuraminic acid content of platelets. Three major ganglioside fractions were identified and characterized. Ganglioside I was hematoside (G(6)) and comprised 92% of the platelet gangliosides. It contained glucose, galactose, a...
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T HE IMPORTANCE of blood platelets in hemostasis is now well established.’ Many of the physiologic properties of platelets suggest the presence of a contractile protein and Bettex-Galland and L#{252}scher ( 1961 ) succeeded in isolating such a contractile protein, thrombosthenin, and studied some of its properties.24 Grette ( 1962 ) confirmed the presence of this protein in pig platelets.5 Sinc...
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labeled membrane proteins by density gradient ultracentrifugation using 1 O%-40% sucrose gradients containing the nonionic detergent. Studies were performed using soluble proteins derived from membranes isolated in the presence or absence of EDTA. Analysis of gradient fractions by SDS-polyacrylamide gel electrophoresis showed that in the absence of divalent cation chelation. GP lIb and lIla pen...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1968
ISSN: 0021-9738
DOI: 10.1172/jci105935